Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines

Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines

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Flavokawain B (1) is a natural chalcone extracted from the roots of Piper methysticum, and has been proven to be a potential cytotoxic compound. Using the partial structure of flavokawain B (FKB), about 23 analogs have been synthesized. Among them, compounds 8, 13 and 23 were found in new FKB deriva...

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Bibliographic Details
Main Authors: Addila Abu Bakar, Muhammad Nadeem Akhtar, Norlaily Mohd Ali, Swee Keong Yeap, Ching Kheng Quah, Wan-Sin Loh, Noorjahan Banu Alitheen, Seema Zareen, Zaheer Ul-Haq, Syed Adnan Ali Shah
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
chalcone synthesis
breast cancer cell lines
SARs
anti-cancer
flavokawain B derivatives
Online Access:http://www.mdpi.com/1420-3049/23/3/616

Internet

http://www.mdpi.com/1420-3049/23/3/616

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