Rod photoreceptor-specific deletion of cytosolic aspartate aminotransferase, GOT1, causes retinal degeneration

Rod photoreceptor-specific deletion of cytosolic aspartate aminotransferase, GOT1, causes retinal degeneration

Photoreceptor cell death is the cause of vision loss in many forms of retinal disease. Metabolic dysfunction within the outer retina has been shown to be an underlying factor contributing to photoreceptor loss. Therefore, a comprehensive understanding of the metabolic pathways essential to photorece...

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Bibliographic Details
Main Authors: Shubha Subramanya, Moloy T. Goswami, Nicholas Miller, Eric Weh, Sraboni Chaudhury, Li Zhang, Anthony Andren, Heather Hager, Katherine M. Weh, Costas A. Lyssiotis, Cagri G. Besirli, Thomas J. Wubben
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Ophthalmology
Subjects:
photoreceptor
GOT1
malate-aspartate shuttle
redox
TCA cycle
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fopht.2023.1306019/full

Internet

https://www.frontiersin.org/articles/10.3389/fopht.2023.1306019/full

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