Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

In this study, we show augmented autophagy in the retinal pigment epithelial cell line ARPE-19 when cultured in the presence of the lipofuscin pigment A2E. A2E alone does not induce RPE cell death, but cell death was induced in the presence of A2E with the autophagy inhibitor 3-methyladenine (3MA),...

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Bibliographic Details
Main Authors: Khandakar A.S.M. Saadat, Yusuke Murakami, Xue Tan, Yoko Nomura, Tsutomu Yasukawa, Eiichi Okada, Yasuhiro Ikeda, Yasuo Yanagi
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Autophagy
Retinal pigment epithelium
Lipofuscin
Mitochondria
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314001090

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http://www.sciencedirect.com/science/article/pii/S2211546314001090

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