Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology

Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology

ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with activin and multiple other ligands including myost...

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Bibliographic Details
Main Authors: Kotaro Sakamoto, Yoko Kanematsu-Yamaki, Yusuke Kamada, Masahiro Oka, Toshiyuki Ohnishi, Masanori Miwa, Taiji Asami, Hiroshi Inooka
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
ActRIIB
Antagonist
Ligand-selectivity
Peptide
Phage display
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580817300584

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http://www.sciencedirect.com/science/article/pii/S2405580817300584

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