The effect of hippocampal NR2B-containing NMDA receptors on chronic cognitive dysfunction in rats with temporal lobe epilepsy

The effect of hippocampal NR2B-containing NMDA receptors on chronic cognitive dysfunction in rats with temporal lobe epilepsy

Abstract Background We have previously reported that hippocampal long-term potentiation (LTP) was suppressed in temporal lobe epilepsy (TLE) rats. The N-methyl-D-aspartic acid receptors containing 2B subunit (NR2B-NMDARs) are indispensable to induce the LTP of hippocampus. However, it is still unkno...

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Bibliographic Details
Main Authors: Xiaoqing Luo, Cheng Li, Xiaoli Yu, Guangtao Kuang, Xiaolu Wang, Jufang Liang, Jun Jiang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Acta Epileptologica
Subjects:
Hippocampus
NR2B-containing NMDA receptors
Chronic cognitive dysfunction
Learning and memory
Temporal lobe epilepsy
Online Access:https://doi.org/10.1186/s42494-022-00111-2

Internet

https://doi.org/10.1186/s42494-022-00111-2

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