Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling

Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling

The cytochrome P450 reductase (POR) transfers electrons to all microsomal cytochrome P450 enzymes (CYP450) thereby driving their activity. In the vascular system, the POR/CYP450 system has been linked to the production of epoxyeicosatrienoic acids (EETs) but also to the generation of reactive oxygen...

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Bibliographic Details
Main Authors: Melina Lopez, Pedro F. Malacarne, Deepak P. Ramanujam, Timothy Warwick, Niklas Müller, Jiong Hu, Matthias Dewenter, Andreas Weigert, Stefan Günther, Ralf Gilsbach, Stefan Engelhardt, Ralf P. Brandes, Flávia Rezende
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Physiology
Subjects:
cytochrome P450 reductase
cardiac remodelling
echocardiography
endothelial cells
cardiac myocytes
transverse aortic constriction
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1056369/full

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https://www.frontiersin.org/articles/10.3389/fphys.2022.1056369/full

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