Pharmacodynamics, Pharmacokinetics, and Antiviral Activity of BAY 81-8781, a Novel NF-κB Inhibiting Anti-influenza Drug

Pharmacodynamics, Pharmacokinetics, and Antiviral Activity of BAY 81-8781, a Novel NF-κB Inhibiting Anti-influenza Drug

Influenza is a respiratory disease that causes annual epidemics. Antiviral treatment options targeting the virus exist, but their efficiency is limited and influenza virus strains easily develop resistance. Thus, new treatment strategies are urgently needed. In the present study, we investigated the...

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Bibliographic Details
Main Authors: Karoline Droebner, Emanuel Haasbach, Sabine E. Dudek, Gerhard Scheuch, Karlheinz Nocker, Sebastian Canisius, Christina Ehrhardt, Georges von Degenfeld, Stephan Ludwig, Oliver Planz
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Microbiology
Subjects:
influenza A virus
antivirals
NF-κB
aspirin
cellular targets
mouse model
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02130/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.02130/full

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