Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes

Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes

Inhibitors (PARPi) of poly(ADP-ribose-)polymerase-1 (PARP1) are used in antitumor therapy; their cytotoxicity correlates with the efficiency of PARP1 trapping in cell chromatin. Previous studies have demonstrated the PARPi-induced trapping of PARP1 on DNA, although details of the mechanism remain co...

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Bibliographic Details
Main Authors: Natalya Maluchenko, Darya Koshkina, Anna Korovina, Vasily Studitsky, Alexey Feofanov
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
poly(ADP-ribose-)polymerase-1
PARP1 inhibitors
talazoparib
olaparib
veliparib
nucleosome
Online Access:https://www.mdpi.com/2073-4409/11/21/3343

Internet

https://www.mdpi.com/2073-4409/11/21/3343

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