Longitudinal Analysis of Brain-Predicted Age in Amnestic and Non-amnestic Sporadic Early-Onset Alzheimer's Disease

Longitudinal Analysis of Brain-Predicted Age in Amnestic and Non-amnestic Sporadic Early-Onset Alzheimer's Disease

Objective: Predicted age difference (PAD) is a score computed by subtracting chronological age from “brain” age, which is estimated using neuroimaging data. The goal of this study was to evaluate the PAD as a marker of phenotypic heterogeneity and severity among early-onset Alzheimer's disease...

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Bibliographic Details
Main Authors: Morgan Gautherot, Grégory Kuchcinski, Cécile Bordier, Adeline Rollin Sillaire, Xavier Delbeuck, Mélanie Leroy, Xavier Leclerc, Jean-Pierre Pruvo, Florence Pasquier, Renaud Lopes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
brain age
deep learning
structural MRI
longitudinal analysis
early-onset Alzheimer's disease
phenotypic variants
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.729635/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.729635/full

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