SPINK1 Overexpression Correlates with Hepatocellular Carcinoma Treatment Resistance Revealed by Single Cell RNA-Sequencing and Spatial Transcriptomics

SPINK1 Overexpression Correlates with Hepatocellular Carcinoma Treatment Resistance Revealed by Single Cell RNA-Sequencing and Spatial Transcriptomics

Low efficacy of treatments and chemoresistance are challenges in addressing refractory hepatocellular carcinoma (HCC). SPINK1, an oncogenic protein, is frequently overexpressed in many HCC cases. However, the impact of SPINK1 on HCC treatment resistance remains poorly understood. Here, we elucidate...

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Bibliographic Details
Main Authors: Chunyuan Yang, Limei Guo, Juan Du, Qiulu Zhang, Lingfu Zhang
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biomolecules
Subjects:
SPINK1
hepatocellular carcinoma
single cell RNA sequencing
spatial transcriptomics
CES2
CYP3A5
Online Access:https://www.mdpi.com/2218-273X/14/3/265

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https://www.mdpi.com/2218-273X/14/3/265

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