Tacrolimus Improves Therapeutic Efficacy of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Diabetic Retinopathy by Suppressing DRP1-Mediated Mitochondrial Fission

Tacrolimus Improves Therapeutic Efficacy of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Diabetic Retinopathy by Suppressing DRP1-Mediated Mitochondrial Fission

Diabetic retinopathy (DR) is a leading cause of blindness in diabetic patients. Umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) are emerging as a promising new drug for degenerative disease associated with diabetes. Recent studies have shown that high glucose-increased excessive calci...

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Bibliographic Details
Main Authors: Hang Hyo Jo, Yeong Seok Goh, Hye Jih Kim, Dae Hyun Kim, Hyemin Kim, Jiyi Hwang, Ji Seung Jung, Nanyoung Kang, Sang Eun Park, Kyung Mee Park, Hyun Jik Lee
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Antioxidants
Subjects:
diabetic retinopathy
mesenchymal stem cells
tacrolimus
mitochondrial dynamics
O-GlcNAc transferase
apoptosis
Online Access:https://www.mdpi.com/2076-3921/12/9/1727

Internet

https://www.mdpi.com/2076-3921/12/9/1727

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