Airway ciliary microenvironment responses in mice with primary ciliary dyskinesia and central pair apparatus defects

Airway ciliary microenvironment responses in mice with primary ciliary dyskinesia and central pair apparatus defects

Abstract Dysfunction of motile cilia can impair mucociliary clearance in the airway and result in primary ciliary dyskinesia (PCD). We previously showed that mutations in central pair apparatus (CPA) genes perturb ciliary motility and result in PCD in mouse models. However, little is known about how...

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Bibliographic Details
Main Authors: Casey W. McKenzie, Reesa M. Wilcox, Oduduabasi J. Isaiah, Michael S. Kareta, Lance Lee
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Motile cilia
Primary ciliary dyskinesia
Central pair
Airway
Single cell RNAseq
Online Access:https://doi.org/10.1038/s41598-024-79877-z

Internet

https://doi.org/10.1038/s41598-024-79877-z

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