Methylglyoxal, a Reactive Glucose Metabolite, Induces Bladder Overactivity in Addition to Inflammation in Mice

Methylglyoxal, a Reactive Glucose Metabolite, Induces Bladder Overactivity in Addition to Inflammation in Mice

Diabetic bladder dysfunction (DBD) is one of the most common complication of diabetes. Methylglyoxal (MGO), a highly reactive dicarbonyl compound formed as a by-product of glycolysis, is found at high levels in plasma of diabetic patients. Here, we explored the effects of chronic administration of M...

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Bibliographic Details
Main Authors: Mariana G. de Oliveira, Matheus L. de Medeiros, Edith B. G. Tavares, Fabiola Z. Mónica, Edson Antunes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
advanced glycation end products
cystometry
transient receptor potential
muscarinic receptors
NF-kB
inducible nitric oxide synthase
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00290/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00290/full

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