Effect of Monoacylglycerol Lipase Inhibition on Intestinal Permeability of Rats With Severe Acute Pancreatitis

Effect of Monoacylglycerol Lipase Inhibition on Intestinal Permeability of Rats With Severe Acute Pancreatitis

Background: Endocannabinoid 2-arachidonoylglycerol (2-AG) is an anti-nociceptive lipid that is inactivated through cellular uptake and subsequent catabolism by monoacylglycerol lipase (MAGL). In this study, we investigated the effects of MAGL inhibition on intestinal permeability and explored the po...

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Bibliographic Details
Main Authors: Jing Wang, Hongwei Xu, Tianjie Chen, Changqin Xu, Xiaohua Zhang, Shulei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
monoacylglycerol lipase
severe acute pancreatitis
intestinal permeability
differentially expressed genes
alternative splicing events
RNA-binding protein
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.869482/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.869482/full

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