Solvent Free Twin Screw Processed Silybin Nanophytophospholipid: In Silico, In Vitro and In Vivo Insights

Solvent Free Twin Screw Processed Silybin Nanophytophospholipid: In Silico, In Vitro and In Vivo Insights

Silybin (SIL) is a polyphenolic phytoconstituent that is commonly used to treat liver disorders. It is difficult to fabricate an orally delivered SIL product due to its low oral bioavailability (0.95%). Therefore, the current research focusses on the development of a novel composition of a phospholi...

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Bibliographic Details
Main Authors: Gasper Fernandes, Sai Lalitha Alekhya Pusuluri, Ajinkya Nitin Nikam, Sumit Birangal, Gautham G. Shenoy, Srinivas Mutalik
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
nanophytophospholipid
phospholipid complex
silybin
twin screw processor
in silico molecular docking and molecular dynamic studies
oral bioavailability enhancement
Online Access:https://www.mdpi.com/1999-4923/14/12/2729

Internet

https://www.mdpi.com/1999-4923/14/12/2729

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