Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology

Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology

Abstract Background Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Magnetic resonance imaging (MRI) has demonstrated its potential for detec...

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Bibliographic Details
Main Authors: Menuka Pallebage-Gamarallage, Sean Foxley, Ricarda A. L. Menke, Istvan N. Huszar, Mark Jenkinson, Benjamin C. Tendler, Chaoyue Wang, Saad Jbabdi, Martin R. Turner, Karla L. Miller, Olaf Ansorge
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Neuroscience
Subjects:
Amyotrophic lateral sclerosis
Magnetic resonance imaging
Post mortem brain
Systematic sampling
Histology
MRI-histology correlation
Online Access:http://link.springer.com/article/10.1186/s12868-018-0416-1

Internet

http://link.springer.com/article/10.1186/s12868-018-0416-1

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