Inhibition of nuclear factor-kappaB, cyclooxygenase-2, and metalloproteinase-9 expression by flavanols from evening primrose (Oenothera paradoxa) in human colon cancer SW-480 cells

Inhibition of nuclear factor-kappaB, cyclooxygenase-2, and metalloproteinase-9 expression by flavanols from evening primrose (Oenothera paradoxa) in human colon cancer SW-480 cells

The present study examines the chemical composition of an evening primrose flavanol preparation (EPFP) and its chemopreventive activity in colon cancer SW-480 cells. EPFP was found to inhibit SW-480 cell viability by 67% vs. controls at 150 µM catechin equivalents (CE) following 72 h incubation (IC5...

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Bibliographic Details
Main Authors: Katarzyna Owczarek, Elżbieta Hrabec, Jakub Fichna, Dorota Sosnowska, Maria Koziołkiewicz, Jacek Szymański, Urszula Lewandowska
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Journal of Functional Foods
Subjects:
Flavanols
Evening primrose
Colon cells
NF-κB
COX-2
MMP-9
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464617304930

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http://www.sciencedirect.com/science/article/pii/S1756464617304930

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