Yeast lacking the sterol C-5 desaturase Erg3 are tolerant to the anti-inflammatory triterpenoid saponin escin

Abstract Escin is a mixture of over 30 glycosylated triterpenoid (saponin) structures, extracted from the dried fruit of horse chestnuts. Escin is currently used as an anti-inflammatory, and has potential applications in the treatment of arthritis and cancer. Engineered yeast would enable production...

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Bibliographic Details
Main Authors: Emily J. Johnston, Jess Tallis, Edward Cunningham-Oakes, Tessa Moses, Simon J. Moore, Sarah Hosking, Susan J. Rosser
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-40308-0