Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats.

Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats.

We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation of ceramide in isolated carotid arteries of SHR leads to vasoconstrictio...

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Main Authors: Léon J A Spijkers, Ben J A Janssen, Jelly Nelissen, Merlijn J P M T Meens, Dayanjan Wijesinghe, Charles E Chalfant, Jo G R De Mey, Astrid E Alewijnse, Stephan L M Peters
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3240660?pdf=render

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http://europepmc.org/articles/PMC3240660?pdf=render

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