Blockade of interferon signaling decreases gut barrier integrity and promotes severe West Nile virus disease

Blockade of interferon signaling decreases gut barrier integrity and promotes severe West Nile virus disease

Abstract The determinants of severe disease caused by West Nile virus (WNV) and why only ~1% of individuals progress to encephalitis remain poorly understood. Here, we use human and mouse enteroids, and a mouse model of pathogenesis, to explore the capacity of WNV to directly infect gastrointestinal...

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Bibliographic Details
Main Authors: Shih-Ching Lin, Fang R. Zhao, Hana Janova, Adrian Gervais, Summer Rucknagel, Kristy O. Murray, Jean-Laurent Casanova, Michael S. Diamond
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41600-3

Internet

https://doi.org/10.1038/s41467-023-41600-3

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