Naringenin and Phytoestrogen 8-Prenylnaringenin Protect against Islet Dysfunction and Inhibit Apoptotic Signaling in Insulin-Deficient Diabetic Mice

Naringenin and Phytoestrogen 8-Prenylnaringenin Protect against Islet Dysfunction and Inhibit Apoptotic Signaling in Insulin-Deficient Diabetic Mice

It has been shown that citrus flavanone naringenin and its prenyl derivative 8-prenylnaringenin (8-PN) possess various pharmacological activities in in vitro and in vivo models. Interestingly, it has been proposed that prenylation can enhance biological potentials, including the estrogen-like activi...

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Bibliographic Details
Main Authors: Song Park, Kyu-Sang Sim, Yeop Hwangbo, Sung-Jin Park, Young-Jun Kim, Jun-Ho Kim
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
naringenin
8-prenylnaringenin
diabetes
islet dysfunction
β-cell apoptosis
estrogen receptor-α
Online Access:https://www.mdpi.com/1420-3049/27/13/4227

Internet

https://www.mdpi.com/1420-3049/27/13/4227

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