Identification and validation of diagnostic biomarkers for intrahepatic cholestasis of pregnancy based on untargeted and targeted metabolomics analyses of urine metabolite profiles

Identification and validation of diagnostic biomarkers for intrahepatic cholestasis of pregnancy based on untargeted and targeted metabolomics analyses of urine metabolite profiles

Abstract Background Intrahepatic cholestasis of pregnancy (ICP) is a prevalent pregnancy-specific complication that presents with maternal itching and elevated serum bile acid levels. ICP is associated with unfavorable pregnancy outcomes, severely decreasing the pregnant woman’s quality of life. Tim...

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Bibliographic Details
Main Authors: Weici Liu, Lingyan Chen, Keyan Miao, Yilan You, Jingyang Li, Jianfeng Lu, Yan Zhang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Pregnancy and Childbirth
Subjects:
Intrahepatic cholestasis of pregnancy
Urine metabolite
Diagnostic biomarker
3-hydroxypropionic acid
Uracil
Online Access:https://doi.org/10.1186/s12884-023-06102-6

Internet

https://doi.org/10.1186/s12884-023-06102-6

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