Inhibition of E2F1/CDK1 pathway attenuates neuronal apoptosis in vitro and confers neuroprotection after spinal cord injury in vivo.

Inhibition of E2F1/CDK1 pathway attenuates neuronal apoptosis in vitro and confers neuroprotection after spinal cord injury in vivo.

Apoptosis of post-mitotic neurons plays a significant role in secondary tissue damage following traumatic spinal cord injury (SCI). Activation of E2F1-dependent transcription promotes expression of pro-apoptotic factors, including CDK1; this signal transduction pathway is believed to represent an im...

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Bibliographic Details
Main Authors: Junfang Wu, Giorgi Kharebava, Chunshu Piao, Bogdan A Stoica, Michael Dinizo, Boris Sabirzhanov, Marie Hanscom, Kelsey Guanciale, Alan I Faden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3405037?pdf=render

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http://europepmc.org/articles/PMC3405037?pdf=render

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