Isogenic human SNCA gene dosage induced pluripotent stem cells to model Parkinson’s disease

Isogenic human SNCA gene dosage induced pluripotent stem cells to model Parkinson’s disease

Alpha-synuclein overexpression and aggregation are critical factors in the pathogenesis of Parkinson’s disease (PD). Clinical cases with alpha-synuclein (SNCA) multiplications or deletions indicate that gene expression levels are essential for neurodegeneration and neurodevelopment. Here, we develop...

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Bibliographic Details
Main Authors: Faria Zafar, Vasavi Nallur Srinivasaraghavan, Max Yang Chen, C. Alejandra Morato Torres, Birgitt Schüle
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Stem Cell Research
Subjects:
Clustered regularly interspaced short palindromic repeat
CRISPR
Cas9
Alpha-synuclein
SNCA
Gene regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506122000824

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http://www.sciencedirect.com/science/article/pii/S1873506122000824

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