Maternal Diabetes Impairs Insulin and IGF-1 Receptor Expression and Signaling in Human Placenta

Maternal Diabetes Impairs Insulin and IGF-1 Receptor Expression and Signaling in Human Placenta

BackgroundMaternal high blood glucose during pregnancy increases the risk for both maternal and fetal adverse outcomes. The mechanisms underlying the regulator effects of hyperglycemia on placental development and growth have not been fully illustrated yet. The placenta expresses high amounts of bot...

Full description

Bibliographic Details
Main Authors: Andrea Tumminia, Nunzio M. Scalisi, Agostino Milluzzo, Giuseppe Ettore, Riccardo Vigneri, Laura Sciacca
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Endocrinology
Subjects:
type 1 diabetes
gestational diabetes
adverse outcomes
HbA1c
placenta
insulin receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.621680/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.621680/full

Similar Items