The ESRP1-GPR137 axis contributes to intestinal pathogenesis

The ESRP1-GPR137 axis contributes to intestinal pathogenesis

Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders. However, it is unclear whether deregulated AS directly contributes to disease. Here, we reveal a critical role of the AS regulator epithelial splicing regulator protein 1 (ESRP1) for intestinal homeostasi...

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Bibliographic Details
Main Authors: Lukas Franz Mager, Viktor Hendrik Koelzer, Regula Stuber, Lester Thoo, Irene Keller, Ivonne Koeck, Maya Langenegger, Cedric Simillion, Simona P Pfister, Martin Faderl, Vera Genitsch, Irina Tcymbarevich, Pascal Juillerat, Xiaohong Li, Yu Xia, Eva Karamitopoulou, Ruth Lyck, Inti Zlobec, Siegfried Hapfelmeier, Rémy Bruggmann, Kathy D McCoy, Andrew J Macpherson, Christoph Müller, Bruce Beutler, Philippe Krebs
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
mRNA alternative splicing
ESRP1
GPR137
intestine
colon cancer
epithelium
Online Access:https://elifesciences.org/articles/28366

Internet

https://elifesciences.org/articles/28366

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