Chemogenetic modulation of sensory afferents induces locomotor changes and plasticity after spinal cord injury

Chemogenetic modulation of sensory afferents induces locomotor changes and plasticity after spinal cord injury

Neuromodulatory therapies for spinal cord injury (SCI) such as electrical epidural stimulation (EES) are increasingly effective at improving patient outcomes. These improvements are thought to be due, at least in part, to plasticity in neuronal circuits. Precisely which circuits are influenced and w...

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Bibliographic Details
Main Authors: Jaclyn T. Eisdorfer, Hannah Sobotka-Briner, Susan Schramfield, George Moukarzel, Jie Chen, Thomas J. Campion, Rupert Smit, Bradley C. Rauscher, Michel A. Lemay, George M. Smith, Andrew J. Spence
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spinal cord injury
clozapine-N-oxide
DREADDs or chemogenetics
Designer Receptors Exclusively Activated by Designer Drugs
kinematics
functional recovery after SCI
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.872634/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.872634/full

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