Interaction and Compatibility Studies in the Development of Olmesartan Medoxomil and Hydrochlorothiazide Formulations under a Real Manufacturing Process

Interaction and Compatibility Studies in the Development of Olmesartan Medoxomil and Hydrochlorothiazide Formulations under a Real Manufacturing Process

A drug–drug and drug–excipient interactions and compatibilities study was conducted for two fixed-dose combination (FDC) products containing olmesartan medoxomil (OLM)/hydrochlorothiazide (HCT) 20/12.5 mg and OLM/HCT 40/12.5 mg during their development including storage. The study consisted of the e...

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Bibliographic Details
Main Authors: Mac Arturo Murillo-Fernández, Ernesto Montero-Zeledón, Ariadna Abdala-Saiz, José Roberto Vega-Baudrit, Andrea Mariela Araya-Sibaja
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
olmesartan medoxomil
hydrochlorothiazide
antihypertensive
solid–state characterization
compatibility study
excipients
Online Access:https://www.mdpi.com/1999-4923/14/2/424

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https://www.mdpi.com/1999-4923/14/2/424

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