Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma
Worldwide, lung cancer, particularly K-ras mutant lung adenocarcinoma (KM-LUAD), is the leading cause of cancer mortality because of its high incidence and low cure rate. To treat and prevent KM-LUAD, there is an urgent unmet need for alternative strategies targeting downstream effectors of K-ras an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/7/1785 |
| _version_ | 1797440052530249728 |
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| author | Michael J. Clowers Seyed Javad Moghaddam |
| author_facet | Michael J. Clowers Seyed Javad Moghaddam |
| author_sort | Michael J. Clowers |
| collection | DOAJ |
| description | Worldwide, lung cancer, particularly K-ras mutant lung adenocarcinoma (KM-LUAD), is the leading cause of cancer mortality because of its high incidence and low cure rate. To treat and prevent KM-LUAD, there is an urgent unmet need for alternative strategies targeting downstream effectors of K-ras and/or its cooperating pathways. Tumor-promoting inflammation, an enabling hallmark of cancer, strongly participates in the development and progression of KM-LUAD. However, our knowledge of the dynamic inflammatory mechanisms, immunomodulatory pathways, and cell-specific molecular signals mediating K-ras-induced lung tumorigenesis is substantially deficient. Nevertheless, within this signaling complexity, an inflammatory pathway is emerging as a druggable target: signal transducer and activator of transcription 3 (STAT3). Here, we review the cell type-specific functions of STAT3 in the pathogenesis and progression of KM-LUAD that could serve as a new target for personalized preventive and therapeutic intervention for this intractable form of lung cancer. |
| first_indexed | 2024-03-09T12:02:35Z |
| format | Article |
| id | doaj.art-4614012c799e4a90858f659890d7be66 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T12:02:35Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4614012c799e4a90858f659890d7be662023-11-30T23:02:01ZengMDPI AGCancers2072-66942022-03-01147178510.3390/cancers14071785Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung AdenocarcinomaMichael J. Clowers0Seyed Javad Moghaddam1Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAWorldwide, lung cancer, particularly K-ras mutant lung adenocarcinoma (KM-LUAD), is the leading cause of cancer mortality because of its high incidence and low cure rate. To treat and prevent KM-LUAD, there is an urgent unmet need for alternative strategies targeting downstream effectors of K-ras and/or its cooperating pathways. Tumor-promoting inflammation, an enabling hallmark of cancer, strongly participates in the development and progression of KM-LUAD. However, our knowledge of the dynamic inflammatory mechanisms, immunomodulatory pathways, and cell-specific molecular signals mediating K-ras-induced lung tumorigenesis is substantially deficient. Nevertheless, within this signaling complexity, an inflammatory pathway is emerging as a druggable target: signal transducer and activator of transcription 3 (STAT3). Here, we review the cell type-specific functions of STAT3 in the pathogenesis and progression of KM-LUAD that could serve as a new target for personalized preventive and therapeutic intervention for this intractable form of lung cancer.https://www.mdpi.com/2072-6694/14/7/1785STAT3lung adenocarcinomaTMEK-rastumor-promoting inflammationmucosal immunology |
| spellingShingle | Michael J. Clowers Seyed Javad Moghaddam Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma Cancers STAT3 lung adenocarcinoma TME K-ras tumor-promoting inflammation mucosal immunology |
| title | Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma |
| title_full | Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma |
| title_fullStr | Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma |
| title_full_unstemmed | Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma |
| title_short | Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma |
| title_sort | cell type specific roles of stat3 signaling in the pathogenesis and progression of k ras mutant lung adenocarcinoma |
| topic | STAT3 lung adenocarcinoma TME K-ras tumor-promoting inflammation mucosal immunology |
| url | https://www.mdpi.com/2072-6694/14/7/1785 |
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