In vitro selection of Giardia duodenalis for Albendazole resistance identifies a β-tubulin mutation at amino acid E198K

In vitro selection of Giardia duodenalis for Albendazole resistance identifies a β-tubulin mutation at amino acid E198K

Benzimidazole-2-carbamate (BZ) compounds, including Albendazole (Alb), are one of just two drug classes approved to treat the gastrointestinal protist Giardia duodenalis. Benzimidazoles bind to the tubulin dimer interface overlapping the colchicine binding site (CBS) of β-tubulin, thereby inhibiting...

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Bibliographic Details
Main Authors: Samantha J. Emery-Corbin, Qiao Su, Swapnil Tichkule, Louise Baker, Ernest Lacey, Aaron R. Jex
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Giardia duodenalis
Albendazole
Benzimidazoles
Drug-resistance
Tubulin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320721000221

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http://www.sciencedirect.com/science/article/pii/S2211320721000221

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