Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM

Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM

Abstract DNA polymerase theta (Polθ) is a DNA helicase-polymerase protein that facilitates DNA repair and is synthetic lethal with homology-directed repair (HDR) factors. Thus, Polθ is a promising precision oncology drug-target in HDR-deficient cancers. Here, we characterize the binding and mechanis...

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Bibliographic Details
Main Authors: Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Robert Betsch, John J. Krais, Bernadette Taberi, Umeshkumar Vekariya, Marissa Calbert, Tomasz Skorski, Neil Johnson, Xiaojiang S. Chen, Richard T. Pomerantz
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51351-4

Internet

https://doi.org/10.1038/s41467-024-51351-4

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