Angioimmunoblastic T-cell lymphoma and correlated neoplasms with T-cell follicular helper phenotype: from molecular mechanisms to therapeutic advances

Angioimmunoblastic T-cell lymphoma and correlated neoplasms with T-cell follicular helper phenotype: from molecular mechanisms to therapeutic advances

Angioimmunoblastic T-cell lymphoma (AITL) is the second most frequent subtype of mature T-cell lymphoma (MTCL) in the Western world. It derives from the monoclonal proliferation of T-follicular helper (TFH) cells and is characterized by an exacerbated inflammatory response and immune dysregulation,...

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Bibliographic Details
Main Authors: Luís Alberto de Pádua Covas Lage, Hebert Fabricio Culler, Cadiele Oliana Reichert, Sheila Aparecida Coelho da Siqueira, Juliana Pereira
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
angioimmunoblastic T-cell lymphoma (AITL)
T-cell follicular helper phenotype (TFH)
epigenetic dysregulation
RhoA G17V mutation
immunodysplastic syndrome
hypomethylating agents (HMAs)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1177590/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1177590/full

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