Promoter Hypomethylation and miR-145-5p Downregulation- Mediated HDAC11 Overexpression Promotes Sorafenib Resistance and Metastasis of Hepatocellular Carcinoma Cells

Promoter Hypomethylation and miR-145-5p Downregulation- Mediated HDAC11 Overexpression Promotes Sorafenib Resistance and Metastasis of Hepatocellular Carcinoma Cells

Sorafenib resistance and tumor metastasis account for poor outcome of hepatocellular carcinoma (HCC). Histone deacetylase 11 (HDAC11) has been reported to exert oncogenic effects in several types of human cancer, but its specific functions and detailed mechanisms in HCC are not fully elucidated. Her...

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Bibliographic Details
Main Authors: Wenlong Wang, Bisha Ding, Weiyang Lou, Shengyou Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hepatocellular carcinoma
sorafenib resistance
metastasis
HDAC11
miR-145-5p
methylation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00724/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00724/full

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