Validation of next-generation sequencing-based chimerism testing for accurate detection and monitoring of engraftment in hematopoietic stem cell transplantation

Validation of next-generation sequencing-based chimerism testing for accurate detection and monitoring of engraftment in hematopoietic stem cell transplantation

Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a life-saving treatment for various hematological disorders. The success of allo-HSCT depends on the engraftment of donor cells and the elimination of recipient cells monitored through chimerism testing. We aimed to validate a next-gen...

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Bibliographic Details
Main Authors: Pramath Kakodkar, Yayuan Zhao, Henry Pan, Fang Wu, Twyla Pearce, Destinie Webster, Mohamed Elemary, Waleed Sabry, Luvinia Kwan, Lindsay Pelzer, Mark Bosch, Karen R. Sherwood, James Lan, Jenny Tran, Robert Liwski, Paul Keown, Ahmed Mostafa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Genetics
Subjects:
next-generation sequencing
chimerism
cell subsets
standardization
proficiency testing
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1282947/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1282947/full

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