Antimalarial target vulnerability of the putative Plasmodium falciparum methionine synthase

Antimalarial target vulnerability of the putative Plasmodium falciparum methionine synthase

Background Plasmodium falciparum possesses a cobalamin-dependent methionine synthase (MS). MS is putatively encoded by the PF3D7_1233700 gene, which is orthologous and syntenic in Plasmodium. However, its vulnerability as an antimalarial target has not been assessed. Methods We edited the PF3D7_1233...

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Bibliographic Details
Main Authors: Nirut Leela, Parichat Prommana, Sumalee Kamchonwongpaisan, Tana Taechalertpaisarn, Philip J. Shaw
Format: Article
Language:English
Published: PeerJ Inc. 2024-01-01
Series:PeerJ
Subjects:
Plasmodium falciparum
Methionine synthase
Malaria
GlmS riboswitch
GlmS ribozyme
Target vulnerability
Online Access:https://peerj.com/articles/16595.pdf

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https://peerj.com/articles/16595.pdf

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