NF-κB mediated regulation of tumor cell proliferation in hypoxic microenvironment

NF-κB mediated regulation of tumor cell proliferation in hypoxic microenvironment

Hypoxia is caused by a cancer-promoting milieu characterized by persistent inflammation. NF-κB and HIF-1α are critical participants in this transition. Tumor development and maintenance are aided by NF-κB, while cellular proliferation and adaptability to angiogenic signals are aided by HIF-1α. Proly...

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Bibliographic Details
Main Authors: Shubham Rastogi, Sara Aldosary, Abdulaziz S. Saeedan, Mohd. Nazam Ansari, Manjari Singh, Gaurav Kaithwas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
lactate shuttle
cancer
HIF-1α
NF-κB
hypoxia
PHD2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1108915/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1108915/full

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