Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)3K

Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)3K

Abstract Given the widespread demand for novel antibacterial agents, we modified a cell-penetrating peptide (KFF)3K to transform it into an antibacterial peptide. Namely, we inserted a hydrocarbon staple into the (KFF)3K sequence to induce and stabilize its membrane-active secondary structure. The s...

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Bibliographic Details
Main Authors: Julia Macyszyn, Piotr Chyży, Michał Burmistrz, Małgorzata Lobka, Joanna Miszkiewicz, Monika Wojciechowska, Joanna Trylska
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-38745-y

Internet

https://doi.org/10.1038/s41598-023-38745-y

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