Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection

Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection

Systems biology can offer a great deal of insight into evolution by quantitatively linking complex properties such as protein structure, folding, and function to the fitness of an organism. Although the link between diseases such as Alzheimer's and misfolding is well appreciated, directly showi...

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Bibliographic Details
Main Authors: Matthew I Peña, Milya Davlieva, Matthew R Bennett, John S Olson, Yousif Shamoo
Format: Article
Language:English
Published: Springer Nature 2010-01-01
Series:Molecular Systems Biology
Subjects:
adenylate kinase
enzyme kinetics
experimental evolution
fitness functions
protein folding
Online Access:https://doi.org/10.1038/msb.2010.43

Internet

https://doi.org/10.1038/msb.2010.43

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