Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue

Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue

Objective: Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) transports Ca2+ from the cytosol into the endoplasmic retitculum (ER) and is essential for appropriate regulation of intracellular Ca2+ homeostasis. The objective of this study was to test the hypothesis that SERCA pumps are involved in the...

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Bibliographic Details
Main Authors: Marco Bauzá-Thorbrügge, Elin Banke, Belén Chanclón, Eduard Peris, Yanling Wu, Saliha Musovic, Cecilia Jönsson, Peter Strålfors, Patrik Rorsman, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Metabolism
Subjects:
Obesity
Adipose tissue
Type-2 diabetes
Endoplasmic reticulum
Adipokine
Brown adipose tissue
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001041

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http://www.sciencedirect.com/science/article/pii/S2212877822001041

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