Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy
Abstract Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic driver mutations in combination with chemotherapy and radiotherapy as well as immunotherapy have benefited cancer patients considerably. Tumor protein p53 (TP53), a crucial tumor suppressor gene encoding...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Cancer Communications |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cac2.12520 |
| _version_ | 1797248673423294464 |
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| author | Bin Song Ping Yang Shuyu Zhang |
| author_facet | Bin Song Ping Yang Shuyu Zhang |
| author_sort | Bin Song |
| collection | DOAJ |
| description | Abstract Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic driver mutations in combination with chemotherapy and radiotherapy as well as immunotherapy have benefited cancer patients considerably. Tumor protein p53 (TP53), a crucial tumor suppressor gene encoding p53, regulates numerous downstream genes and cellular phenotypes in response to various stressors. The affected genes are involved in diverse processes, including cell cycle arrest, DNA repair, cellular senescence, metabolic homeostasis, apoptosis, and autophagy. However, accumulating recent studies have continued to reveal novel and unexpected functions of p53 in governing the fate of tumors, for example, functions in ferroptosis, immunity, the tumor microenvironment and microbiome metabolism. Among the possibilities, the evolutionary plasticity of p53 is the most controversial, partially due to the dizzying array of biological functions that have been attributed to different regulatory mechanisms of p53 signaling. Nearly 40 years after its discovery, this key tumor suppressor remains somewhat enigmatic. The intricate and diverse functions of p53 in regulating cell fate during cancer treatment are only the tip of the iceberg with respect to its equally complicated structural biology, which has been painstakingly revealed. Additionally, TP53 mutation is one of the most significant genetic alterations in cancer, contributing to rapid cancer cell growth and tumor progression. Here, we summarized recent advances that implicate altered p53 in modulating the response to various cancer therapies, including chemotherapy, radiotherapy, and immunotherapy. Furthermore, we also discussed potential strategies for targeting p53 as a therapeutic option for cancer. |
| first_indexed | 2024-04-24T20:18:20Z |
| format | Article |
| id | doaj.art-462640d709de4fed9ad7c074b145a36c |
| institution | Directory Open Access Journal |
| issn | 2523-3548 |
| language | English |
| last_indexed | 2024-04-24T20:18:20Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Communications |
| spelling | doaj.art-462640d709de4fed9ad7c074b145a36c2024-03-22T11:52:53ZengWileyCancer Communications2523-35482024-03-0144329736010.1002/cac2.12520Cell fate regulation governed by p53: Friends or reversible foes in cancer therapyBin Song0Ping Yang1Shuyu Zhang2Laboratory of Radiation Medicine West China Second University Hospital Sichuan University Chengdu Sichuan P. R. ChinaLaboratory of Radiation Medicine West China Second University Hospital Sichuan University Chengdu Sichuan P. R. ChinaLaboratory of Radiation Medicine West China Second University Hospital Sichuan University Chengdu Sichuan P. R. ChinaAbstract Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic driver mutations in combination with chemotherapy and radiotherapy as well as immunotherapy have benefited cancer patients considerably. Tumor protein p53 (TP53), a crucial tumor suppressor gene encoding p53, regulates numerous downstream genes and cellular phenotypes in response to various stressors. The affected genes are involved in diverse processes, including cell cycle arrest, DNA repair, cellular senescence, metabolic homeostasis, apoptosis, and autophagy. However, accumulating recent studies have continued to reveal novel and unexpected functions of p53 in governing the fate of tumors, for example, functions in ferroptosis, immunity, the tumor microenvironment and microbiome metabolism. Among the possibilities, the evolutionary plasticity of p53 is the most controversial, partially due to the dizzying array of biological functions that have been attributed to different regulatory mechanisms of p53 signaling. Nearly 40 years after its discovery, this key tumor suppressor remains somewhat enigmatic. The intricate and diverse functions of p53 in regulating cell fate during cancer treatment are only the tip of the iceberg with respect to its equally complicated structural biology, which has been painstakingly revealed. Additionally, TP53 mutation is one of the most significant genetic alterations in cancer, contributing to rapid cancer cell growth and tumor progression. Here, we summarized recent advances that implicate altered p53 in modulating the response to various cancer therapies, including chemotherapy, radiotherapy, and immunotherapy. Furthermore, we also discussed potential strategies for targeting p53 as a therapeutic option for cancer.https://doi.org/10.1002/cac2.12520cancerchemotherapydrug targetingimmunotherapyp53tumor suppressor |
| spellingShingle | Bin Song Ping Yang Shuyu Zhang Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy Cancer Communications cancer chemotherapy drug targeting immunotherapy p53 tumor suppressor |
| title | Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy |
| title_full | Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy |
| title_fullStr | Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy |
| title_full_unstemmed | Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy |
| title_short | Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy |
| title_sort | cell fate regulation governed by p53 friends or reversible foes in cancer therapy |
| topic | cancer chemotherapy drug targeting immunotherapy p53 tumor suppressor |
| url | https://doi.org/10.1002/cac2.12520 |
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