The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation

The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation

Abstract Background Aseptic Loosening (AL) following periprosthetic osteolysis is the main long-term complication after total joint arthroplasty (TJA). However, there is rare effective treatment except for revision surgery, which is costly and painful to the patients. In recent years, the ketone bod...

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Bibliographic Details
Main Authors: Yanglin Wu, Yun Teng, Chenhui Zhang, Ying Pan, Qin Zhang, Xu Zhu, Naicheng Liu, Xinlin Su, Jun Lin
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Nanobiotechnology
Subjects:
β-hydroxybutyrate
NLRP3 inflammasome
Osteoclast
Osteolysis
Wear particles
Online Access:https://doi.org/10.1186/s12951-022-01320-0

Internet

https://doi.org/10.1186/s12951-022-01320-0

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