Unravelling the Complex Denaturant and Thermal-Induced Unfolding Equilibria of Human Phenylalanine Hydroxylase

Unravelling the Complex Denaturant and Thermal-Induced Unfolding Equilibria of Human Phenylalanine Hydroxylase

Human phenylalanine hydroxylase (PAH) is a metabolic enzyme involved in the catabolism of L-Phe in liver. Loss of conformational stability and decreased enzymatic activity in PAH variants result in the autosomal recessive disorder phenylketonuria (PKU), characterized by developmental and psychologic...

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Bibliographic Details
Main Authors: María Conde-Giménez, Javier Sancho
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
phenylalanine hydroxylase
phenylketonuria
protein stability
protein folding
pharmacological chaperone
Online Access:https://www.mdpi.com/1422-0067/22/12/6539

Internet

https://www.mdpi.com/1422-0067/22/12/6539

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