The combined effects of amino acid substitutions and indels on the evolution of structure within protein families.

BACKGROUND: In the process of protein evolution, sequence variations within protein families can cause changes in protein structures and functions. However, structures tend to be more conserved than sequences and functions. This leads to an intriguing question: what is the evolutionary mechanism by...

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Bibliographic Details
Main Authors: Zheng Zhang, Yuxiao Wang, Lushan Wang, Peiji Gao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3001449?pdf=render