Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts

Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts

Abstract Background The senescence of dermal fibroblasts (DFLs) leads to an imbalance in the synthesis and degradation of extracellular matrix (ECM) proteins, presenting so-called senescence-associated secretory phenotype (SASP), which ultimately leads to skin aging. Recently, mesenchymal stem cell...

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Bibliographic Details
Main Authors: Xiangnan Zhao, Yue Liu, Pingping Jia, Hui Cheng, Chen Wang, Shang Chen, Haoyan Huang, Zhibo Han, Zhong-Chao Han, Krzysztof Marycz, Xiaoniao Chen, Zongjin Li
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Stem Cell Research & Therapy
Subjects:
Extracellular vesicles (EVs)
Chitosan hydrogel
Dermal fibroblasts (DFLs)
Skin aging
Extracellular matrix (ECM)
Online Access:https://doi.org/10.1186/s13287-021-02262-4

Internet

https://doi.org/10.1186/s13287-021-02262-4

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