Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7

Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7

Point mutations in the genes encoding the skeletal muscle isoforms of tropomyosin can cause a range of muscle diseases. The amino acid substitution of Arg for Pro residue in the 90th position (R90P) in γ-tropomyosin (Tpm3.12) is associated with congenital fiber type disproportion and muscle weakness...

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Bibliographic Details
Main Authors: Yurii S. Borovikov, Daria D. Andreeva, Stanislava V. Avrova, Vladimir V. Sirenko, Armen O. Simonyan, Charles S. Redwood, Olga E. Karpicheva
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
tropomyosin
mutations in tropomyosin
muscle weakness
congenital myopathy
Ca<sup>2+</sup>-sensitivity of myofilament
ATPase activity of myosin
Online Access:https://www.mdpi.com/1422-0067/22/12/6318

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https://www.mdpi.com/1422-0067/22/12/6318

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