Regulation of low-density lipoprotein receptor expression in triple negative breast cancer by EGFR-MAPK signaling

Abstract Expression of the low-density lipoprotein receptor (LDLR) has been shown to play a critical role in hypercholesterolemia-associated breast cancer growth and is associated with shorter recurrence-free survival in human breast cancer studies. We sought to identify how circulating LDL choleste...

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Bibliographic Details
Main Authors: Tiffany Scully, Nathan Kase, Emily J. Gallagher, Derek LeRoith
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97327-y