A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response

A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response

Abstract Antibiotic-induced dysbiosis is a major risk factor for Clostridioides difficile infection (CDI), and fecal microbiota transplantation (FMT) is recommended for treating CDI. However, the underlying mechanisms remain unclear. Here, we show that Tritrichomonas musculis (T.mu), an integral mem...

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Bibliographic Details
Main Authors: Huan Yang, Xiaoxiao Wu, Xiao Li, Wanqing Zang, Zhou Zhou, Yuan Zhou, Wenwen Cui, Yanbo Kou, Liang Wang, Ankang Hu, Lianlian Wu, Zhinan Yin, Quangang Chen, Ying Chen, Zhutao Huang, Yugang Wang, Bing Gu
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47075-0

Internet

https://doi.org/10.1038/s41467-024-47075-0

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