A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response

A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response

Abstract Antibiotic-induced dysbiosis is a major risk factor for Clostridioides difficile infection (CDI), and fecal microbiota transplantation (FMT) is recommended for treating CDI. However, the underlying mechanisms remain unclear. Here, we show that Tritrichomonas musculis (T.mu), an integral mem...

Bibliografski detalji
Glavni autori:	Huan Yang, Xiaoxiao Wu, Xiao Li, Wanqing Zang, Zhou Zhou, Yuan Zhou, Wenwen Cui, Yanbo Kou, Liang Wang, Ankang Hu, Lianlian Wu, Zhinan Yin, Quangang Chen, Ying Chen, Zhutao Huang, Yugang Wang, Bing Gu
Format:	Članak
Jezik:	English
Izdano:	Nature Portfolio 2024-04-01
Serija:	Nature Communications
Online pristup:	https://doi.org/10.1038/s41467-024-47075-0

Slični predmeti

Identification of Clostridioides difficile-Inhibiting Gut Commensals Using Culturomics, Phenotyping, and Combinatorial Community Assembly
od: Sudeep Ghimire, i dr.
Izdano: (2020-02-01)

Characterizing arginine, ornithine, and putrescine pathways in enteric pathobionts
od: Ian M. Lillie, i dr.
Izdano: (2024-04-01)

Bacillus velezensis DSM 33864 reduces Clostridioides difficile colonization without disturbing commensal gut microbiota composition
od: Ida Søgaard Larsen, i dr.
Izdano: (2023-09-01)

Antibiotic resistance and genomic features of Clostridioides difficile in southwest China
od: Wenpeng Gu, i dr.
Izdano: (2022-09-01)

Editorial: Clostridioides difficile infection
od: Guido Granata, i dr.
Izdano: (2024-02-01)

Pathogenicity and virulence of Clostridioides difficile
od: Jessica E. Buddle, i dr.
Izdano: (2023-12-01)

Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against <i>Clostridioides difficile</i> by Commensal <i>Clostridium</i>
od: Amber D. Reed, i dr.
Izdano: (2021-02-01)

Clostridioides difficile infection in the Asia-Pacific region
od: Deirdre A. Collins, i dr.
Izdano: (2020-01-01)

Lipid Species in the GI Tract are Increased by the Commensal Fungus <i>Candida albicans</i> and Decrease the Virulence of <i>Clostridioides difficile</i>
od: Jesus A. Romo, i dr.
Izdano: (2020-07-01)

Epidemiology of Clostridioides difficile in South Africa.
od: Pieter de Jager, i dr.
Izdano: (2021-01-01)

Cutting edges in Clostridioides difficile infections
od: Ana Durovic, i dr.
Izdano: (2021-10-01)

Characterizing the flavodoxin landscape in Clostridioides difficile
od: Daniel Troitzsch, i dr.
Izdano: (2024-03-01)

Bacterial metabolites influence the autofluorescence of Clostridioides difficile
od: Taylor D. Ticer, i dr.
Izdano: (2024-10-01)

Impaired arginine/ornithine metabolism drives severe HFMD by promoting cytokine storm
od: Yaozhong Zhang, i dr.
Izdano: (2024-06-01)

Opportunities for Nanomedicine in <i>Clostridioides difficile</i> Infection
od: Pei-Wen Wang, i dr.
Izdano: (2021-08-01)

Gut metabolites predict Clostridioides difficile recurrence
od: Dawkins, Jennifer J., i dr.
Izdano: (2022)

Expansion of a versatile pathogen: Clostridioides difficile
od: Tereena Lucas, i dr.
Izdano: (2024-12-01)

Role of glycogen metabolism in Clostridioides difficile virulence
od: Md Kamrul Hasan, i dr.
Izdano: (2024-09-01)

The role of gut fungi in Clostridioides difficile infection
od: Lamei Wang, i dr.
Izdano: (2024-06-01)

Spores of Clostridioides difficile are toxin delivery vehicles
od: Carolina P. Cassona, i dr.
Izdano: (2024-07-01)

An integrated pipeline for prediction of Clostridioides difficile infection
od: Jiang Li, i dr.
Izdano: (2023-10-01)

<i>Clostridioides difficile</i> Infection in Kidney Transplant Recipients
od: UZhe Ding, i dr.
Izdano: (2024-02-01)

Membrane vesicles of clostridioides difficile and other clostridial species
od: Goh, Shan, i dr.
Izdano: (2024)

Advances in diagnostic assays for Clostridioides difficile infection in adults
od: Dong-ang Liu, i dr.
Izdano: (2024-12-01)

Clostridioides difficile infection: a changing treatment paradigm
od: Yousif Al Naser, i dr.
Izdano: (2024-03-01)

Modern approaches to the immunotherapy of <i>Clostridioides difficile</i>
od: K. E. Popruga, i dr.
Izdano: (2024-01-01)

Fight or flee, a vital choice for Clostridioides difficile
od: Ji Zeng, i dr.
Izdano: (2024-03-01)

Clostridioides difficile Infection: Targeting an Unwelcome and Persistent Threat
od: Hann Moir
Izdano: (2023-05-01)

Introduction to the Special Issue on <i>Clostridioides difficile</i>
od: Guido Granata, i dr.
Izdano: (2021-10-01)

An Update on <i>Clostridioides difficile</i> Binary Toxin
od: Adrián Martínez-Meléndez, i dr.
Izdano: (2022-04-01)

Clostridioides Difficile Enteritis: Case Report and Literature Review
od: Artsiom Klimko, i dr.
Izdano: (2022-02-01)

Fecal Microbiota Transplantation beyond Clostridioides Difficile Infection
od: Chang Mo Moon, i dr.
Izdano: (2021-03-01)

<i>Clostridioides difficile</i>, a New “Superbug”
od: Rumyana Markovska, i dr.
Izdano: (2023-03-01)

Current Diagnostic and Treatment Approach of Clostridioides difficile Infection
od: Bella Yunita, i dr.
Izdano: (2023-04-01)

An intact S-layer is advantageous to Clostridioides difficile within the host.
od: Michael J Ormsby, i dr.
Izdano: (2023-06-01)

An intact S-layer is advantageous to Clostridioides difficile within the host
od: Michael J. Ormsby, i dr.
Izdano: (2023-06-01)

Outbreak of Clostridioides difficile infection in Silesian district hospital
od: Klaudia T. Szarek, i dr.
Izdano: (2023-06-01)

Impact of Clostridioides difficile Reporting on Antimicrobial Therapy Days Directed at Treatment of C. difficile Infections
od: Ardath Plauche, i dr.
Izdano: (2024-07-01)

Host-defense piscidin peptides as antibiotic adjuvants against Clostridioides difficile.
od: Adenrele Oludiran, i dr.
Izdano: (2024-01-01)

Host-defense piscidin peptides as antibiotic adjuvants against Clostridioides difficile
od: Adenrele Oludiran, i dr.
Izdano: (2024-01-01)