Osteoking promotes bone formation and bone defect repair through ZBP1–STAT1–PKR–MLKL-mediated necroptosis

Osteoking promotes bone formation and bone defect repair through ZBP1–STAT1–PKR–MLKL-mediated necroptosis

Abstract Background Osteoking has been used for fracture therapy with a satisfying clinical efficacy. However, its therapeutic properties and the underlying mechanisms remain elusive. Method A bone defect rat model was established to evaluate the pharmacological effects of Osteoking by the dynamic o...

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Bibliographic Details
Main Authors: Suya Zhang, Yudong Liu, Zhaochen Ma, Shuangrong Gao, Lin Chen, Honggang Zhong, Chu Zhang, Tao Li, Weiheng Chen, Yanqiong Zhang, Na Lin
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Chinese Medicine
Subjects:
Bone defect repair
Bone formation
Osteoking
Necroptosis
Transcriptome-based network investigation
Online Access:https://doi.org/10.1186/s13020-024-00883-4

Internet

https://doi.org/10.1186/s13020-024-00883-4

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