mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice

mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice

Abstract Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the mammalian target of rapamycin complex 1 (mTORC1) regulates proteostasis in skeletal muscle by affecting protein synthesis and autophagosom...

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Bibliographic Details
Main Authors: Alexander S. Ham, Kathrin Chojnowska, Lionel A. Tintignac, Shuo Lin, Alexander Schmidt, Daniel J. Ham, Michael Sinnreich, Markus A. Rüegg
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Raptor
Muscle atrophy
Protein translation
Fibre‐type
TOP mRNA
Online Access:https://doi.org/10.1002/jcsm.12505

Internet

https://doi.org/10.1002/jcsm.12505

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